Publications 2022-2025
142. Harnessing zebrafish as a model for photopharmacology: Insights into light-controlled biological effects of photoswitchable drugs
Drug Disc. Today, ASAP
G. Pietro da Silva, J. Doorduin, W. Szymanski, R. Souza da Silva, P. H. Elsinga,* C. Denise Bonan*
141. Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation
J. Mater. Chem. A, ASAP
A. Lasorsa, P. van der Meulen, E. Naumann, M. M. Lerch, M. R. Marquez-Garcia, X. Lan, K. Loos, B. L. Feringa, W. Szymanski, P. van der Wel*
140. Green-light-activatable penicillin for light-dependent spatial control of bacterial growth, biofilm formation and in vivo infection treatment
ACS Cent. Sci. 2025, 11, 1083-1093
A. M. Schulte, J. W. A. Schoenmakers, M. van Oosten, P. C. Jutte, J. M. van Dijl,* W. Szymanski,* B. L. Feringa*
139. Photo-Amygdalin: Light-dependent control over hydrogen cyanide release and cytotoxicity
Chem. Sci. 2025, 16, 10585-10594
A. M. Schulte, A. Guinart, G. Alachouzos, W. Szymanski,* B. L. Feringa*
138. Manipulation of Chemistry and Biology with Visible Light Using tetra-ortho-Substituted Azobenzenes and Azonium Ions
Angew. Chem. Int. Ed. 2025, e202423506
F. Cardano*, R. Márquez García, W. Szymanski*
137. Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement
EJNMMI 2025, 52, 3877–3890
G. B. Spoelstra, P. H. Elsinga, J. M. van Dijl, J. H. van Snick, B. L. Feringa, A. W. J. M. Glaudemans, B. Keizers, S. Kruijff, W. Szymanski, M. van Oosten, F. F. A. IJpma*
136. Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging
EJNMMI Radiopharmacy & Chemistry 2025, 110, 7
H. Helbert, W. Deuther-Conrad, M. de Haan, B. Wenzel, G. Luurtsema, W. Szymanski, P. Brust, R.A.J.O. Dierckx, B. L. Feringa, P. H. Elsinga*
135. Spatiotemporal control over circadian rhythms with light
Med. Res. Rev. 2025, 45, 968-984
D. Kolarski*, W. Szymanski*, B.L. Feringa*
134. Bacteria-targeted imaging using vancomycin-based positron emission tomography tracers can distinguish infection from sterile inflammation
EJNMMI 2025, 52, 1878–1889
G. B. Spoelstra, L. M. Braams, F. F. A. IJpma, M. van Oosten, B. L. Feringa, W. Szymanski, P. H. Elsinga, J. M. van Dijl*
133. Photocleavable Protecting Groups Using a Sulfite Self-Immolative Linker for High Uncaging Quantum Yield and Aqueous Solubility
Angew. Chem. Int. Ed. 2024, e202411380
A. M. Schulte, Q. Vivien, J. H. Leene, G. Alachouzos,* B.L. Feringa,* W. Szymanski*
132. Modulation of the Isomerization of Iminothioindoxyl Switches by Supramolecular Confinement
ChemComm 2024, 60, 9388-9391
D. Doellerer, A.-K. Rückert, S. Doria, M. Hilbers, N. A. Simeth, W. J. Buma, M. Di Donato,* B. L. Feringa,* W. Szymanski,* S. Crespi*
131. Synthesis and preclinical evaluation of [18F]AlF-NODA-MP-C6-CTHRSSVVC as a PET tracer for CD163-positive tumor-infiltrating macrophages
Nucl. Med. Biol. 2024, 138-139, 108946
B. Fernandes, I. F. Antunes, K. Prasad, D. A. Vazquez-Matias, E. Preusser De Mattos, W. Szymanski, C. M. Moriguchi Jeckel, E.F.J. de Vries, P. H. Elsinga*
130. Visible and near-infrared light-induced photoclick reactions
Nat. Rev. Chem. 2024, 8, 665-685
Y. Fu, N. A. Simeth, W. Szymanski,* B. L. Feringa*
129. Getting a molecular grip on the half-lives of iminothioindoxyl photoswitches
Chem. Sci. 2024, 15, 14379 - 14389
M. E. Boëtius, M. W.H. Hoorens, M. Oštadnický, A. Laurent, M. di Donato, A. C. A. van Wingaarden, M. F. Hilbers, B. L. Feringa, W. J.Buma,* M. Medved,* W. Szymanski*
128. With or without a co-solvent? Highly efficient ultrafast Phenanthrenequinone-Electron Rich Alkene (PQ-ERA) photoclick reactions
Chem. Sci. 2024, 15, 11557-11563
A. M. Doze, Y. Fu, M. Di Donato, M. F. Hilbers, G. Luurtsema, P. H. Elsinga, W. J. Buma, W. Szymanski,* B. L. Feringa*
127. Towards medical imaging of drug photoactivation: development of light responsive MRI and CEST contrast agents
Smart Molecules 2024, 2, e20230029
I. M. Welleman, C. L. F. van Beek, I. Belcin, A. M. Schulte, R. A. J. O. Dierckx, B. L. Feringa, H. H. Boersma, W. Szymanski*
126. Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography
EJNMMI 2024, 51, 2583-2569
G. B. Spoelstra, S. N. Blok, L. Reali Nazario, L. Noord, Y. Fu, N. A. Simeth, F. F. A. IJpma, M. van Oosten, J. M. van Dijl, B. L. Feringa, W. Szymanski, P. H. Elsinga*
125. Triplet-Triplet Energy Transfer: A Simple Strategy for an Efficient Visible Light-Induced Photoclick Reaction
Angew. Chem. Int. Ed. 2024, 63, e202319321
Y. Fu, G. Alachouzos, N. A. Simeth, M. Di Donato, M. F. Hilbers, W. J. Buma, W. Szymanski,* B. L. Feringa*
124. Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein
ACS Chem. Bio. 2024, 19, 451-461
J. Volaric, N. J. van der Heide, N. L. Mutter, D. F. Samplonius, W. Helfrich, G. Maglia*, W. Szymanski*, and B. L. Feringa*
123. Photocontrol of the ß-Hairpin Polypeptide Structure through an Optimized Azobenzene-Based Amino Acid Analogue
J. Am. Chem. Soc. 2024, 146, 2062-2071
R. Parlato, J. Volaric, A. Lasorsa, M. Bagherpoor Helabad, P. Kobauri, G. Jain, M. Miettinen, B. L. Feringa,* W. Szymanski,* P. C. A. van der Wel*
122. The Fate of the Contact Ion Pair Determines the Photochemistry of Coumarin-Based Photocleavable Protecting Groups
Chem. Sci. 2024, 15, 2062-2073
A. M. Schulte, G. Alachouzos,* W. Szymanski,* Ben L. Feringa,*
121. Cation Delocalization and Photo-isomerization Enhance the Uncaging Quantum Yield of a Photocleavable Protecting Group
Chem. Comm. 2024, 60, 578-581
A. M. Schulte, L. M. Smid, G. Alachouzos, W. Szymanski,* Ben L. Feringa,*
120. Towards molecular imaging-guided intervention theatres in oncology (Editorial)
EJNMMI 2023, editorial
J. Vonk, S. Kruijff, R. H. J. A. Slart, W. Szymanski, M. J. H. Witjes, A. W. J. M. Glaudemans*
119. Development of a smart MRI and CEST contrast agent for the imaging of sulfatase activity
Pharmaceuticals 2023, 16, 1439
I. M. Welleman, F. Reeßing, H. H. Boersma, R. A.J.O. Dierckx, B. L. Feringa, W. Szymanski*
118. Efficient, Near-infrared Light-induced Photoclick Reaction enabled by Upconversion Nanoparticles
Adv. Funct. Mater. 2023, 33, 2306531
Y. Fu, K. Wu, G. Alachouzos, N. A. Simeth, T. Freese, M. Falkowski, W. Szymanski,* H. Zhang,* B. L. Feringa*
117. Mechanistic basis for red light switching of azonium ions
J. Am. Chem. Soc. 2023, 145, 36, 19894–19902
M. Medved, M. Di Donato, W. J. Buma, A. D. Laurent, L. Lameijer, T. Hrivnák, I. Romanov, S. Tran, B. L. Feringa, W. Szymanski,* G. A. Woolley*
116. Establishing PQ-ERA Photoclick Reactions with Unprecedented Efficiency by Engineering of the Nature of the Phenanthraquinone Triplet State
Chem. Sci. 2023, 14, 7465-7474
Y. Fu, G. Alachouzos, N. A. Simeth, M. Di Donato, M. F. Hilbers, W. J. Buma,* W. Szymanski,* B. L. Feringa*
115. Rational Design in Photopharmacology with Molecular Photoswitches
Angew. Chem. Int. Ed. 2023, 62, e202300681
P. Kobauri, F. J. Dekker, W. Szymanski,* B. L. Feringa*
114. Activiteit van geneesmiddelen reguleren met licht
Ned. Tijdschr. Geneeskd. 2023, 167, D7444
I. M. Welleman, W. Szymanski*
113. Molecular engineering to enhance reactivity and selectivity in an ultrafast photoclick reaction
Angew. Chem. Int. Ed. 2023, 62, e202218203
Y. Fu, N. A. Simeth, R. Toyoda, R. Brilmayer, W. Szymanski,* B. L. Feringa*
112. Patient-derived parathyroid organoids as a tracer and drug-screening application model
Stem Cell Rep. 2022, 17, 2518-2530
M. E. Noltes. L. H.J.Sondorp, L. Kracht, I. F. Antunes, R. Wardenaar, W. Kelder, A. Kemper, W. Szymanski, W. T. Zandee, L. Jansen, A. H. Brouwers, R. P. Coppes, S. Kruijff
111. Design and Synthesis of Visible Light-responsive Azobenzene Building Blocks for Chemical Biology
J. Org. Chem. 2022, 87, 14319–14333
J. Volaric, J. Buter, A. M. Schulte, K.-O. van den Berg, E. Santamaría-Aranda, W. Szymanski,* B. L. Feringa*
110. Photoswitchable, Water-soluble Bis-azobenzene Cross-linkers with Enhanced Properties for Biological Applications
ChemPhotoChem 2022, 6, e202200170
J. Volaric, S. Thallmair, B. L. Feringa,* W. Szymanski*
109. A Strategy for Engineering High Photolysis Efficiency of Photocleavable Protecting Groups Through Cation Stabilization
J. Am. Chem. Soc. 2022, 144, 12421-12430
A. Schulte, G. Alachouzos,* W. Szymanski,* and B.L. Feringa*
108. Light-Control over Casein Kinase 1delta Activity with Photopharmacology: A Clear Case for Arylazopyrazole-Based Inhibitors
Int. J. Mol. Sci. 2022, 23, 5326
A. Schulte, D. Kolarski, V. Sundaram, A. Srivastava, F. Tama, B.L. Feringa,* W. Szymanski*
107. Hypothesis-Driven, Structure-based Design in Photopharmacology: the Case of eDHFR Inhibitors
J. Med. Chem. 2022, 65, 4798–4817
P. Kobauri, N. Galenkamp, A. Schulte, J. de Vries, N. A. Simeth, G. Maglia, S. Thallmair, D. Kolarski, W. Szymanski,* B. L. Feringa*
106. A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET
EJNMMI Radiopharmacy and Chemistry 2022, 7, 3
H. Helbert, E. M. Ploeg, D. F. Samplonius, S. N. Blok, I. F. Antunes, V. I. Böhmer, G. Luurtsema, R. A. J. O. Dierckx, B. L. Feringa, P. H. Elsinga,* W. Szymanski,* W. Helfrich
105. Computational Design, Synthesis, and Photochemistry of Cy7PPG, an Efficient NIR-Activated Photolabile Protecting Group for Therapeutic Applications
Angew. Chem. Int. Ed. 2022, 61, e202201308
G. Alachouzos, A. M. Schulte, A. Mondal, W. Szymanski,* B. L Feringa*
