Functional molecules: Photopharmacology
P1: Photocontrolled HDAC inhibitor

Key features: P1 is a potent HDAC2 inhibitor that increases its activity 40x upon irradiation with UV light, reaching IC50 of 0.55 µM. The cis isomer also shows higher toxicity to cancer cells. The activity of P1 is retained in adult mouse brains.
Photochemistry: 365 nm / white light; Half-life: hours
Creators: Wiktor Szymanski, Marilena Ourailidou
P2: Photocontrolled BRAFV600E inhibitor

Key features: P2 is a photoswitchable inhibitor of the BRAF kinase that reversibly increases its potency 10-fold under irradiation with UV light.
Photochemistry: 365 nm / white light; Half-life: hours
Creators: Wiktor Szymanski, Mark Hoorens
Literature: paper 1
P3: Photocontrolled glutamate transport inhbitors

Key features: P3 is a photoswitchable glutamate transport inhibitor that enables reversible control of the function of ley glutamate transporters.
Photochemistry: 365 nm / white light; Half-life: hours
Creators: Mark Hoorens, Haigen Fu
P4: Photoactivated dopamine

Key features: P4 responds to red light by releasing dopamine.
Photochemistry: 650 nm
Creators: Kaja Sitkowska
Literature: paper 1
P5: Photoswitchable FraC nanopore

Key features: P5 is the Y140C mutant of cytotoxic FraC nanopore, in which the introduced cysteine is modified with a polar azobenzene switch. It enables reversible control of the insertion of FraC into the memberanes of mammalian cells and its toxicity.
Photochemistry: 365 nm / White light
Creators: Jana Volaric, Natalie Mutter
Literature: paper 1
P6: Photoswitchable circadian rhythm regulator
Key features: P6 is a Longdaysin-based, visible-light responsive regulator of circadian rhythm period that enables the regulation of period and phase in cells and tissues. It acts as a light-controlled inhibitor of CKI kinases.
Photochemistry: green (530 nm) / violet (400 nm) light
Creators: Dusan Kolarski
Literature: paper 1